Sumerianz Journal of Medical and Healthcare
Online ISSN: 2663-421X
Print ISSN: 2706-8404
Quarterly Published (4 Issues Per Year)
Journal Website: https://www.sumerianz.com/?ic=journal-home&journal=31Archive
Volume 8 Issue 1 (2025)
Complicated Skin Ulcer from Misdiagnosis and Inappropriate Treatment of a Cutaneous Leishmaniasis Lesion. Case Report
Authors : Néstor Añez; Agustina Rojas; Gladys Crisante; José V. Scorza-Dagert; Johnny Bullón
DOI : doi.org/10.47752/sjmh.8.1.18.21
Abstract:Introduction. American cutaneous leishmaniasis, a sand fly transmitted neglected tropical disease caused by Leishmania spp. parasites, is endemic in most Latin-American countries. Case report. We present a 54-year-old-woman case, showing a grade II ulcer in the left leg’s malleolar zone with a presumptive clinical diagnosis of skin neoplasia lesion. For 6 weeks this patient received antibiotic treatment after being subject to a surgical skin grafting. However, biopsies from the ulcer did not reveal neoplasia components, the lesion was unresponsive to antibiotic therapy and reject the skin grafting. The ulcer was treated with antibiotic for six additional weeks, without size reduction. Months later, we diagnosed the patient’s lesion as leishmaniasis, based on: i. positive Leishmanin skin test, ii. detection of amastigotes from the lesion and iii. positive PCR assay. Treatment with a pentavalent antimony compound was administered in a perilesional infiltration (PLI) combined with daily applications of an antimony based nanoemulsion cream. After 60 days of treatment, the ulcer was observed epithelialized with a scar. Conclusion. Combined Sb5+-PLI-meglumine antimoniate and nanoemulsion cream, is a cost effective and safe anti leishmanial therapy option, accessible to all people, including the poorest of the poor infected with cutaneous leishmaniasis.
Pages: 18-21
Phytochemical, Proximate, Mineral Composition and Antioxidant Property of Moringa Oleifera Leaf Meal from Two Different Locations in Ghana
Authors : William Kwajo Jimah Kwenin
DOI : doi.org/10.47752/sjmh.81.6.17
Abstract:Moringa oleifera leaf meal (MOLM) was analyzed in triplicate to determine proximate, mineral, energy, phytochemical profile and antioxidant potential. Data was analysed using STATISTIX 9.0. and means separated by least significant difference at 5 %. Dry matter (9.50 - 9.77 %), crude protein (27.42 - 27.72 %), crude fat (4.55 - 4.65 %), crude fibre (10.37 - 10.56 %), ash (12.98 - 13.39 %), carbohydrate (34.21 - 34.74 %) and gross energy (17.77 - 17.82 MJ/kg) were recorded. Minerals determined were Ca (655.93 - 656.31 mg/kg), Fe (70.21 - 71.60 mg/kg), K (257.72 - 266.58 mg/kg), Mg (69.74 - 73.49 mg/kg), Mn (12.32 - 12.64 mg/kg), P (586.31 - 597.69 mg/kg) and Zn (16.68 - 16.75 mg/kg). Alkaloids, coumarins, flavonoids, saponins, steroids, sterols, tannins and terpenoids were detected. Quantitative analysis gave alkaloids (2.60 - 2.70 %), flavonoids (27.01 - 28.00 mgCE/mg), saponnins (1.54 - 1.57 %), tannins (49.26 - 49.76 mgTAE/g), total phenols (106.42 - 106.44 mg/g), oxalate (1.10 - 1.42 mg/g) and phytates (11.51 - 11.72 mg/g). Higher scavenging ability of MOLM of 2,2-diphenyl-1-picrylhydrazyl than vitamin C make MOLM a suitable natural antioxidant. MOLM has adequate amounts of crude protein, minerals and energy, useful phytochemicals and high antioxidant potential.
Pages: 6-17
Biotransformation of Dehydroepiandrosterone by Aspergillus Species and A Comparison of the Results with Previous Studies
Authors : Raghda Mahmood Abdulghafoor Al-ani
DOI : doi.org/10.47752/sjmh.81.1.5
Abstract:Steroids are widespread in nature, being found in animals, plants, fungi, and certain bacteria. Microbial transformation found wide applications in biotransformation of steroids in order to obtain stereoselective products. This work will explain how to incubate DHEA alongside Aspergillus glaucus MRC 200914 in order to understand the way of this fungus metabolizes the substrate. The main outcome of incubating DHEA with Aspergillus glaucus in this study was the production of several hydroxylated metabolites.
Pages: 1-5