Sumerianz Journal of Biotechnology

Online ISSN: 2617-3050
Print ISSN: 2617-3123

Quarterly Published (4 Issues Per Year)

Journal Website:


Volume 1 Issue 1 (2018)

Antagonistic Effect of Probiotics on Recurring Infectious Diseases

Authors : Abbas Abel Anzaku ; Fajingbesi A. O. ; Onah Daniel Oche ; Angbalaga A. G. ; Lennox J. A.
Probiotics are normal microbiota that are said to antagonize the activities of microbial pathogens of human through mechanisms such as colonizing and preventing microbial multiplicity in the human body system. This study however reviewed the antagonistic potential of probiotics against recurring infectious pathogens as well as the global threats of antimicrobial resistance using extensive literature search. Based on this study, a number of probiotic strains have been identified with antimicrobial potential against pathogenic organisms and could be helpful in combating the current trends of recurrent infectious diseases and the advent of continuous resistant microbial strains. The study recommends the need to study these beneficial strains at the genomic level and their mechanisms of antagonism on infectious pathogens while further study on discovering more probiotic strains is strongly advocated.

Pages: 30-33

Soft Drinks Associate with Low Levels of Some Bone and Infertility Markers in Women

Authors : Amadu A. A. ; Kabir N. ; Bolori M. T. ; Ahmad I. M. ; Yunusa I.
The consumption of soft drinks has increased drastically over the decades; important concerns raised are the medical and health implications of the increased consumption. We aimed to assess the effect of soft drink consumption on the serum levels of some bone and infertility markers in women. The biochemical investigations for serum calcium and phosphorus concentrations was carried out with Random Access Biochemistry auto-analyzer (KENZA 240 TX) using Bio-Labo diagnostics kits, while serum hormonal levels; prolactin, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), progesterone, estrogen and vitamin D were assayed using Abbot Architect i1000 SR (USA) reagents. A total of 128 newly diagnosed women with primary infertility were screened; out of which 112 (87.5%) consumed soft drinks while 16 (12.5%) do not. Sixty-eight (53.1%) participants consumed more than 4 bottles per day and orange soft drinks happens to be the drink of choice for 40 (31.2%) participants. A significantly high level of serum inorganic phosphate (P < 0.05) in subject that consumed soft drinks was observed. Serum levels of calcium and vitamin D showed no significant difference (P > 0.05) with consumption. Serum level of progesterone was observed to be significantly (P < 0.05) low in subjects consuming soft drinks. Consumption of soft drinks might be associated with high inorganic phosphates and reduced serum level of serum progesterone.

Pages: 25-29

Pollution Potential of Effluent from Challawa Industrial Layout and its Influence on the Water Quality of River Challawa, Kano, Nigeria

Authors : Udiba U. U. ; Odey M. O. ; Lydia E. Udofia
Indicators of water quality are constituents that are measured through analysis and used to estimate the water quality status of a given sample of water. The physicochemical parameters of effluent discharged from Challawa industrial layout, Kano and its influence on the surface water quality of the receiving River Challawa, was investigated between March and June 2016 using standard analytical methods. Results indicated that both effluent and surface water showed the ranges 28.6-30.2 oC and 27.56-28.23 oC for temperature, 8.72-889 and 7.23-7.65 for pH, 3404-3844 mg/l and 2237-2499 mg/l for Total Dissolved Solids (TDS), 3667-4212 mg/l and 2435-3143 mg/l for Total Suspended Solids (TSS) and, 5602-6543 µs/cm and 1792-1954 µs/cm for Electrical Conductivity (EC). Metal concentrations of the effluents and surface water ranged from 0.86-1.49 mg/l and 0.72-1.08 for lead (Pb), 0.82-0.98 and 0.12-0.31mg/l for cadmium (Cd), 0.64-9.98 mg/l and 1.42-2.48 mg/l for chromium (Cr) and, 2.46-3.57 mg/l and 0.82-2.05 mg/l for zinc (Zn). All through the study EC, TDS, TSS, Pb, Cd, Cr, and Zn contents of effluent were found to be above the Nigerian Environmental Standards and Regulations Enforcement Agency’s acceptable limit for the discharge of industrial effluents into surface water. Cd, Cr and Zn concentrations were above the Australian and New Zealand Environment and Conservation Council limits for irrigation water. The concentrations of the parameters in surface water were also found to be above World Health organization (WHO) and the Nigerian Standard for Drinking Water Quality (NSDWQ) acceptable limits for portable water. Statistical analysis revealed that effluent discharged from Challawa industrial layout has significant adverse influence on the overall water quality of River Challawa. Extraction of the effluent for irrigation purposes or surface water of the river for domestic or industrial purposes poses serious toxicological risk to human health.

Pages: 12-24

Comparison of the Acute Erythropoietic Capacities of Erythropoietin and U-74389G Concerning Mean Corpuscular Hemoglobin Levels

Authors : Tsompos C. ; Panoulis C. ; Toutouzas K. ; Triantafyllou A. ; Zografos C. G. ; Papalois A. ; Tsarea K. ; Karamperi M.
Aim: This study compared the erythropoietic capacities of erythropoietin (Epo) and antioxidant drug U-74389G based on 2 preliminary studies. The provided results at mean corpuscular hemoglobin (MCH) levels augmentation were co-evaluated in a hypoxia reoxygenation protocol of an animal model.Materials and methods: MCH levels (MCHl) were evaluated at the 60th reoxygenation min (for groups A, C and E) and at the 120th reoxygenation min (for groups B, D and F) in 60 rats. Groups A and B received no drugs, rats from groups C and D were administered with Epo; whereas rats from groups E and F were administered with U-74389G. Results: The first preliminary study of Epo non significantly increased the MCHl by 0.31%+0.16% (p-value=0.4430). However, the second preliminary study of U-74389G significantly rised the MCHl by 1.37%+0.37% (p-value=0.0005). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has 4.362893-fold erythropoietic potency than Epo (p-value=0.0000). Conclusions: The anti-oxidant capacities of U-74389G accelerate the acute erythropoietic properties; presenting 4.362893-fold erythropoietic rise than epo (p-value=0.0000).

Pages: 7-11

Breeding Model of White Lupine Cultivar

Authors : Georgieva N. ; Kosev V.
In order to increase the productive potential of plant species, it is necessary to develop models for selection of genetically significant traits. In the present research 23 white lupine cultivars were studied with a purpose to determine the influence of basic traits on their productivity by a regression model and select suitable parental components for the needs of combinative breeding. The results showed that the linear component in the regression of seed productivity in white lupine regarding the studied quantitative traits was statistically significant and considerable. The highest relative share on seed productivity had the growth rate (+ 43.367), the number of seeds per plant (+0.321) and plant weight (+ 0.266). The breeding model of plant in white lupine has the following characteristics: vegetative period ≤ 98 days, growth rate ≥ 0.71, plant height 36-71 cm, aboveground mass ≥ 44 g, number of pods 13-16, number of seeds ≥ 69, number of seeds in a pod 3-4, mass of 1000 seeds ≥ 298 g. From the white lupine cultivars studied in our collection, promising to realize this model are Astra, Tel Keram, Termis Mestnii and Solnechnii that can be included in hybridization schemes in the breeding-improvement work of this crop. Choosing suitable parents in the combined breeding by using the simplex method will allow targeted planning of the breeding process to development of high-productive cultivars in shorter terms.

Pages: 1-6